汉塞尔(约翰·卡梅隆·米切尔 John Cameron Mitchell 饰)从小就被摇滚乐吸引,希望以后能够成为一名摇滚乐歌手,某日,他遇见了美国大兵卢瑟(毛里斯·迪恩·温特 Maurice Dean Wint 饰),卢瑟答应带他去美国,但前提是汉塞尔必须和他结婚。为了追寻自己的梦想,汉塞尔毅然进行了变性手术,虽然手术给他带来了永久的创伤,但汉塞尔总算踏上了美国的土地。 两年之后,卢瑟抛弃了汉塞尔,在这片举目无亲的土地上,汉塞尔顽强的生存着。他为自己找了一份看护的工作,还成立了名为“The Angry Inch”的摇滚乐队,在此期间,汉塞尔遇见了名为汤米(迈克尔·皮特 Michael Pitt 饰)的年轻男孩,殊不知这个男孩将会成为他日后的噩梦。
In San Francisco, the sportsman Kay Hoog tells to the members of a club that he has found a message in a bottle with a map from a Harvard's missing professor telling about a treasure of an Inca lost civilization still alive. He decides to go to Peru to seek the gold. However, members of the secret criminal organization The Spiders leaded by Lio Sha break in Kay's mansion during the night and steal the map. Kay Hoog travels to Peru, where he retrieves his map and a document about the Diamond Ship from The Spiders. Later he saves the Priestess of the Sun Naela and brings her to San Francisco. However, The Spiders kill Naela and Kay Hoog promises revenge for the death of his love